TRPP Totally Explained

Everything about Trpp totally explained

TRPP is a family of transient receptor potential ion channels mutations of which are involved in polycystic kidney disease. Hence the name TRPP is an acronym derived from the phrase Transient Receptor Potential Polycystic.

Subcategories

TRPP subunits can be divided into two subcategories depending on structural similarity.

TRPP1-like

The first group, TRPP1-like, contains TRPP1, PKDREJ, PKD1L1, PKD1L2, and PKD1L3. TRPP1 contains numerous N-terminal adhesive domains that are important for cell-cell contact. This group of subunits also contain a large extracellular domain with numerous polycystin motifs. These motifs are of unknown function and are located between the S6 and S7 segments. The large intracellular C-terminal segment of TRPP1 seems to interact with TRPP2 to act as a signaling complex.

TRPP2-like

The other group of TRPP members are TRPP2-like: TRPP2, TRPP3, and TRPP5. Unlike the TRPP1-like group, which contain 11 membrane-spanning segments, the TRPP2-like group resemble other TRP channels, having 6 membrane-spanning segments with intracellular N- and C-termini. All of the members of this group contain a coiled coil region in their C-terminus involved in the interaction with the TRPP1-like group. TRPP2 and TRPP3 form constitutively active cation-selective ion channels that are permeable to calcium. TRPP3 has also been implicated in sour taste perception. Coupling of TRPP1 and TRPP2 recruits TRPP2 to the membrane. Here, its activity is decreased and it suppresses the activation of G proteins by TRPP1.

Genes

Group 1: polycystic kidney disease 1 (PKD1 or TRPP1) like proteins
- PKD1 (TRPP1)
Group 2: polycystic kidney disease 2 (PKD2 or TRPP2) like proteins
- PKD2 (TRPP2)
- (TRPP3)
- (TRPP5)

Further Information

Get more info on 'Trpp'.

External Link Exchanges

Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:

<a href="http://trpp.totallyexplained.com">TRPP Totally Explained</a>

Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned.